TRANSFORMATION OF 2-BENZOYLAMINO-1-(?-NAPHTHYL)PROPAN-1-OL INTO 4-METHYL-1-PHENYL BENZO[f] ISOQUINOLINE RATHER THAN ITS 3-SUBSTITUTED ISOMER

نویسندگان: ثبت نشده
چکیده مقاله:

The necessary conditions to transform hydroxyamide (1) and 2-oxazolines (2, 3) into 3- or 4-methyl benzo[f] isoquinolines (4, 5) has been established. The mechanism of these reactions has been proposed claiming the existence of the protonated 2-oxazoline (6) and the styrylamides (7) as intermediates.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

transformation of 2-benzoylamino-1-(?-naphthyl)propan-1-ol into 4-methyl-1-phenyl benzo[f] isoquinoline rather than its 3-substituted isomer

the necessary conditions to transform hydroxyamide (1) and 2-oxazolines (2, 3) into 3- or 4-methyl benzo[f] isoquinolines (4, 5) has been established. the mechanism of these reactions has been proposed claiming the existence of the protonated 2-oxazoline (6) and the styrylamides (7) as intermediates.

متن کامل

Synthesis and Antimicrobial Activity of Some 2-[(4-Substituted-Phenyl-3-Chloro-Azetidin-2-One)-5-(2'-Methylamino-4-Phenyl-1', 3'-Thiazolyl-]-1, 3,4-Thiadiazoles

A new 2-[(4-substituted-phenyl-3-chloroazetidin-2-one)-5-(2'-methylamino 4-phenyl-1', 3'-thiazolyl-]-1, 3, 4-thiadiazoles, 5(a-n) were synthesized from 2-substituted-benzylideneamino-5-[2'-methylamino-4'-phenyl-1',3'-thiazolyl]-1,3, 4-thiadiazole, 4(a-n) using 2-amino-4phenyl-1, 3-thiazole as a starting material. The synthesised compounds have been screened in vitro for their antimicrobial acti...

متن کامل

3-Phenyl-1-[2-(3-phenyl­isoquinolin-1-yl)­diselan­yl]isoquinoline

The complete molecule of the title compound, C(30)H(20)N(2)Se(2), is generated by a crystallographic inversion centre at the mid-point of the Se-Se bond. The dihedral angle between the isoquinoline-1-selenol group and the phenyl ring is 14.92 (2)°. The herringbone-like packing of the structure is supported by inter-molecular π-π stacking inter-actions with a shortest perpendicular distance betw...

متن کامل

synthesis and antimicrobial activity of some 2-[(4-substituted-phenyl-3-chloro-azetidin-2-one)-5-(2'-methylamino-4-phenyl-1', 3'-thiazolyl-]-1, 3,4-thiadiazoles

a new 2-[(4-substituted-phenyl-3-chloroazetidin-2-one)-5-(2'-methylamino 4-phenyl-1', 3'-thiazolyl-]-1, 3, 4-thiadiazoles, 5(a-n) were synthesized from 2-substituted-benzylideneamino-5-[2'-methylamino-4'-phenyl-1',3'-thiazolyl]-1,3, 4-thiadiazole, 4(a-n) using 2-amino-4phenyl-1, 3-thiazole as a starting material. the synthesised compounds have been screened in vitro for their antimicrobial acti...

متن کامل

Isoquinoline Promoted Synthesis of alkyl 2-(1-alkyl-5-oxo-3-phenyl-2-thioxotetrahydro-4H-imidazol-4-yliden) acetate derivatives

Derivatives of thiazolidinone ring systems are known to act as anti-HIV infections , analgesic, anti-bacterial, anti-convulsant, anti parasitic, potential anti-inflammatory and herbicidal agents. Due biological activities of thiazolidinones ring, several methods for their synthesis have been illustrated in literature. Imidazolidine-2-thiones were synthesized by the oxidative cyclization of 1-be...

متن کامل

(2E)-3-(4-Bromo­phen­yl)-1-(2-methyl-4-phenyl-3-quinol­yl)prop-2-en-1-one

The conformation about the ethene bond [1.316 (3) Å] in the title compound, C(25)H(18)BrNO, is E. The quinoline ring forms dihedral angles of 67.21 (10) and 71.68 (10)° with the benzene and bromo-substituted benzene rings, respectively. Highlighting the non-planar arrangement of aromatic rings, the dihedral angle formed between the benzene rings is 58.57 (12)°.

متن کامل

منابع من

با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ذخیره در منابع من قبلا به منابع من ذحیره شده

{@ msg_add @}


عنوان ژورنال

دوره 12  شماره 1

صفحات  -

تاریخ انتشار 2001-03-01

با دنبال کردن یک ژورنال هنگامی که شماره جدید این ژورنال منتشر می شود به شما از طریق ایمیل اطلاع داده می شود.

کلمات کلیدی

میزبانی شده توسط پلتفرم ابری doprax.com

copyright © 2015-2023